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Human Document Project - introduction, goals & myself

Human Document Project - introduction, goals & myself

... talk given at KIST Europe, Saarbrücken. Human Document Project workshop, June 30 - July 2, 2010.

andreas manz

June 30, 2010
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  1. introduction goals & myself
    introduction, goals & myself
    Andreas Manz
    h l f f b
    FRIAS School of Soft Matter, Freiburg Germany
    KIST Europe, Saarbrücken Germany

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  2. part 1
    part 1

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  3. miniaturization
    down-scaling
    engineering

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  4. objects which have a reason for
    their si e
    their size
    ?
    ?

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  5. objects which don’t have a reason
    for their si e
    for their size

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  6. typical lengths
    yp g
    5
    1
    1/20
    1/20
    1/200
    1/200,000

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  7. human perception
    p p
    < 1 cm is small
    < 1 cm is small
    > 2 m is large
    g
    < 100ms is fast
    > 10 i i l
    > 10 min is slow

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  8. keep an eye on
    p y
    time scale !

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  9. micromachining
    clean room technology
    photolithography
    photolithography
    etching / deposition
    etching / deposition

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  10. “l b hi ”
    “lab on a chip”
    microfabrication
    microfabrication
    microfluidics
    μTAS
    miniaturized total analysis systems

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  11. capillary electrophoresis on chip
    1989-91

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  12. flow injection analysis, 1989-92

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  13. for more information on the topic
    for more information on the topic
    micro TAS conference
    G i th
    Groningen, the
    Netherlands 2010
    impact factor 6.5
    1,000 attendees annually
    p f
    Reviews on Micro total analysis systems
    in Anal.Chem. 2002, 04, 06, 08 and 10
    cited over 3,000 times

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  14. part 2
    part 2

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  15. electrophoresis
    p

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  16. 10 fold miniaturization
    100 x faster separation
    p
    1000 x smaller volume
    10 x lower reagent consumption

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  17. double stranded DNA separation

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  18. reaction with intercalating dye

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  19. part 3
    part 3

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  20. „the human document project“
    p j

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  21. „the human document project“
    p j
    goal
    t d 1 d t b t h
    •to produce 1 document about human
    culture, science, arts etc.
    culture, science, arts etc.
    •to preserve it for 1 million years

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  22. keep an eye on
    p y
    time scale !

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  23. 1 million years back
    1 million years back
    Homo neanderthalensis
    Homo sapiens
    Homo heidelbergensis
    Homo habilis
    Homo erectus
    Paranthropus
    Ardipithecus
    Australopithecus
    6 5 4 3 2 1 0 million years

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  24. 1 million years back
    1 million years back
    5 4 3 2 1 0
    venus statuettes, cave paintings
    pottery
    pottery
    stone axes
    pebble tools

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  25. „the human document project“
    p j
    Lespugue, upper paleolithic, 25,000 B.C.

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  26. „the human document project“
    p j
    Lascaux cave, upper paleolithic, 14,000 B.C.

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  27. „the human document project“
    p j
    Tartaria tablets, 5,500 B.C. Jiahu symbols, 6,000 B.C.

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  28. „the human document project“
    p j
    Epic of Gilgamesh
    p g
    begins with instructions on
    how to find a box of copper
    ow to d a bo o coppe
    inside a foundation stone in the
    great walls of Uruk
    3,000 B.C.

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  29. „the human document project“
    p j
    Egyptian tombs are also time capsules

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  30. „the human document project“
    p j
    time capsule
    1939
    crypt of
    civilization,
    Oglethorpe
    University,
    Atlanta Georgia
    Atlanta, Georgia

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  31. „the human document project“
    p j
    Pioneer plaque 1972, Voyager CD 1977

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  32. „the human document project“
    p j
    Th L N F d ti  D i l
    The Long Now Foundation  Daniel
    Hillis, San Francisco
    ,
    The Ozymandias Project  David Green,
    New York
    New York

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  33. …books last a few hundred years
    …boo s s ew u d ed ye s

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  34. …or a few thousand
    …o ew ous d

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  35. …ceramics or stone last longer
    …ce cs o s o e s o ge

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  36. old monocrystalline material
    y
    lasted for millions of years

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  37. deep etching of monocrystalline silicon
    deep e c g o o oc ys e s co

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  38. embedding it in amber
    e bedd g be
    resin source today
    Agathis australis (New Zealand)
    monomer: communic acid
    monomer: communic acid

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  39. the oldest digital document on this planet
    e o des d g docu e o s p e
    … is DNA
    d t i
    and proteins
    for many protein sequences,
    the evolution can be tracked
    the evolution can be tracked
    back 1,000,000,000 or
    2,000,000,000 years

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  40. age of proteins
    ge o p o e s
    Evolutionary Horizons (Million years)
    Fibrinopeptides 200 Mammalian Radiation
    L t lb i 670 V t b t
    Lactalbumins 670 Vertebrates
    Ribonucleases 850 Animals
    Hemoglobins 1 500 Plants/Animals
    Hemoglobins 1,500 Plants/Animals
    Acid Proteases 2,300 Prokayrotic/Eukarotic
    adapted from R.F.Doolittle et al., Cold Spring Harb. Symp. Quant. Biol.,
    51:447–455, 1986
    ,

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  41. age of proteins
    ge o p o e s
    source W. R. Pearson (2000) "Protein sequence comparison and protein
    evolution“ ISMB2000 - Tutorial, San Diego, CA.

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  42. encoding it in DNA
    e cod g N
    deep sea shark
    deep sea shark
    long generations
    little variation in DNA
    link to essential protein
    link to essential protein
    or: abundant microorgansim?

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  43. dumping Wikipedia
    dumping Wikipedia
    on the moon
    meteorite-safe deposit
    meteorite safe deposit
    labelling location visible from earth
    lti l i
    multiple copies

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  44. what kind of information will be
    important to mankind in 1 million years?
    important to mankind in 1 million years?
    subjective or objective?
    what defines / describes our culture of
    h d t d ?
    here and today?

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  45. how to make sure, it can be understood?
    Rosetta stone-like or children’s learning-
    like?
    like?
    computer code, English or pictograms /
    h t ?
    photos?

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  46. learning / definitions
    Lik R tt t
    Like Rosetta stone

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  47. learning / definitions
    lik hild ’ l i
    like children’s learning

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  48. where to distribute it? in what numbers?
    how to get attention?
    how to get attention?
    it shouldn’t be found too early, or too
    late / not at all?
    late / not at all?
    near Gizeh? London? Baltic Sea? Gobi
    d t b f Chi ?
    desert or urban areas of China?

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  49. attract attention
    c e o

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  50. attract attention by fluorescence
    ( ti l / t d t )
    (nanoparticles / quantum dots)

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  51. include a timer
    cocktail of radioactive isotopes?
    p
    description of our calender and
    astronomic event?

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  52. include a timer
    cocktail of radioactive isotopes?
    aluminium26, magnesium26 720.000y
    uranium234, thorium230 80.000y
    , y
    uranium235, protactinium231 34.300y
    carbon14 5.730y

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  53. one astronomic event…
    Easter
    Island

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  54. … may not be enough
    Easter
    Island

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  55. should it be a monograph?
    could it be parts of a puzzle, referring to
    each other?
    each other?
    d fi i i i d i / l i d
    definitions, introduction / learning and
    then chapter in maximum encoding
    e c p e u e cod g
    density?

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  56. brainstorming
    brainstorming
    workshop
    June 30- July 2, 2010
    Saarbrücken
    Saarbrücken

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  57. purpose of this workshop
    what do we want?
    what do we want?
    who are we?
    di th bl
    discuss the problems
    networking
    g
    “white paper” - goals
    “road map” time frame milestones
    road map – time frame, milestones

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  58. purpose of this workshop
    “white paper”
    white paper
    define goals
    ll
    overall
    for each discipline
    p
    (create a paper for ourselves, funding
    bodies press students)
    bodies, press, students)

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  59. purpose of this workshop
    “road map”
    d fi k
    define tasks
    disciplines, regions, indivduals
    p , g ,
    avoid too much duplication
    ifi ll b ti
    specific collaborations
    kick start the “bigger”
    gg
    (put together what we intend to do)

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  60. publications
    open access e-only journal
    “Ch ll ”
    “Challenges”
    published by MDPI Basel
    p y
    special issue “Human Document”

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