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on nanofluidics and why it is so great

on nanofluidics and why it is so great

... given jointly with Jan Eijkel at GRC, Oxford 2005.

andreas manz

August 08, 2005
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  1. LATERNA MAGICA

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  2. REFE
    RENC
    E

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  3. LATERNA MAGICA

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  4. GLASS GLASS DEVICE

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  5. LATERNA MAGICA

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  6. THE OLDE BUNNY TRICK

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  7. MY
    LATEST
    AIR
    PUMP

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  8. THE OLDE BUNNY TRICK

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  9. THE OLDE BUNNY TRICK

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  10. microfluidics

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  11. Microf
    luidics

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  12. waves

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  15. On nanofluidics and why
    it’s so great
    S. Holmes, Baker Street, London

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  16. DNA research
    confinement & reading
    Tegenfeldt 2004,
    Craighead group
    Kasianowicz , 1996

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  17. Nanotechnology: spatial design instead
    of randomness
    Korda, 2002
    Huang, 2004
    Continuous flow!

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  18. Thermal ratchets: employ noise
    Koss, 2003
    Bader, 2004
    Separation speed scales with 1/d2 !

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  19. Actin-myosin movement by ATP-biased
    Brownian motion (Kitamura 1999)

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  20. Rustom, 2004

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  21. Natura artis magistra
    (or: bottom-up and top-down)
    There’s plenty of sophistication at the bottom

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  22. Bottom-up:
    Aquaporins
    specific transport

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  23. proton transport blocked
    Water dipole reorientation  no
    dipole chain 
    no Grotthus proton conduction
    Tajkhorshid et al., Science, 296 (2002) 525

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  24. Aquaporin
    http://www.ks.uiuc.edu/Research/aquaporins/

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  25. Bottom-up:
    Na+ K+ ATPase
    active transport through cell wall

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  26. Separation!

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  27. • Na+/K+ separating force (Energy / distance ) : 1ATP /
    (membrane thickness) = 14 kT / 4 nm  14 pN
    • Pumps against E-field of 70 mV / 4 nm = 1.75e7 V/m
    • Electrophoresis: max. 2e5 V/m  0.03 pN on unit charge
    • Almost isothermal, ~ 100% efficiency
    • Energy dissipation only where needed

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  29. Combining top/down and bottom/up
    Cornell, 1997

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  30. Why nanofluidics is so great
    • Single molecule studies
    • Freedom of nanoarchitecture instead of random
    separation structure
    – Sophisticated sieving (continuous flow), ratchets
    • From nature: active transport for separation
    – efficient
    – high separating field gradients
    – specific

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  31. Now, isn’t that great???

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