on nanofluidics and why it is so great

on nanofluidics and why it is so great

... given jointly with Jan Eijkel at GRC, Oxford 2005.

3014362bc816c0e34f9bb270d226e31c?s=128

andreas manz

August 08, 2005
Tweet

Transcript

  1. LATERNA MAGICA

  2. REFE RENC E

  3. LATERNA MAGICA

  4. GLASS GLASS DEVICE

  5. LATERNA MAGICA

  6. THE OLDE BUNNY TRICK

  7. MY LATEST AIR PUMP

  8. THE OLDE BUNNY TRICK

  9. THE OLDE BUNNY TRICK

  10. microfluidics

  11. Microf luidics

  12. waves

  13. None
  14. None
  15. On nanofluidics and why it’s so great S. Holmes, Baker

    Street, London
  16. DNA research confinement & reading Tegenfeldt 2004, Craighead group Kasianowicz

    , 1996
  17. Nanotechnology: spatial design instead of randomness Korda, 2002 Huang, 2004

    Continuous flow!
  18. Thermal ratchets: employ noise Koss, 2003 Bader, 2004 Separation speed

    scales with 1/d2 !
  19. Actin-myosin movement by ATP-biased Brownian motion (Kitamura 1999)

  20. Rustom, 2004

  21. Natura artis magistra (or: bottom-up and top-down) There’s plenty of

    sophistication at the bottom
  22. Bottom-up: Aquaporins specific transport

  23. proton transport blocked Water dipole reorientation  no dipole chain

     no Grotthus proton conduction Tajkhorshid et al., Science, 296 (2002) 525
  24. Aquaporin http://www.ks.uiuc.edu/Research/aquaporins/

  25. Bottom-up: Na+ K+ ATPase active transport through cell wall

  26. Separation!

  27. • Na+/K+ separating force (Energy / distance ) : 1ATP

    / (membrane thickness) = 14 kT / 4 nm  14 pN • Pumps against E-field of 70 mV / 4 nm = 1.75e7 V/m • Electrophoresis: max. 2e5 V/m  0.03 pN on unit charge • Almost isothermal, ~ 100% efficiency • Energy dissipation only where needed
  28. None
  29. Combining top/down and bottom/up Cornell, 1997

  30. Why nanofluidics is so great • Single molecule studies •

    Freedom of nanoarchitecture instead of random separation structure – Sophisticated sieving (continuous flow), ratchets • From nature: active transport for separation – efficient – high separating field gradients – specific
  31. Now, isn’t that great???

  32. None